Laryngeal cartilage defect repair with allogenic chondrocyte-PGA complex
Abstract：Objective To explore the ability to repair laryngeal cartilagedefects using chondrocyte-polyglycolic acid(PGA)complexes.Method Chondrocytes were isolated from costa-cartilage of infant rabbits by Ⅱ type collagenase digestion.they were cultured in vitro for 2～3 generations with Ham-F12,and then the cells were cultured in PGA scaffolds.Result cartilaginors matrix was observed 7～10 days after culturing.4weeks after operation,laryngeal cartilage defects were initally filled with new cartilage.No scar and necrosis in operative areas were found.More chondrocytes and matrix were observed in reparative areas.Conclusion Chondrocyte-PGA complex can be used as reparative material for laryngeal thyroid cartilage defect.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 43-44 )