The mechanism of the lurg injury after global ischemia in rats
Abstract：Objective To explore the mechanism of the lung injury induced bytransient global ischemia,the distribution of substance P(SP) and SP receptor in rats lung were observed.Method 12 rats were exploited.They were divided into two groups, the global ischemia group(I group,n=6) and control group(C group, n=6).Two group animals were slaughtered after given anesthesia.The lung frozen sections were collected and stained by the methods of hematoxylin and eosin(HE) and immunohistochemistry.Result a decreased positive immunoreactivity for SP and SP receptors was found in the bronchus mucous membrane and the epithelial and endothelial cell of blood vessels after global ischemia.Conclusion Global ischemia can induce inflammation and a significant decrease in distribution of SP and SP receptor in rats lung.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 42-43 )