Meta-Analysis of Radical Prostatectomy Combined with Endocrine Therapy for Oligometastatic Prostate Cancer
Dong Yujie
Luo Jin
Li Zhuoran
Chen Zhiqiang
Jia Yuqi
Liu Qiwei
Li Jinqiao
Yang Qiming
Wang Chao
Wang Baojun
Abstract：Objective To systematically evaluate the effect of radical prostatectomy(RP)combined with endocrine therapy on the prognosis of patients with oligometastatic prostate cancer(OmPCa).Methods In this study,OmPCa was clearly defined as 1-5 bone and/or lymph node metastatic lesions(excluding visceral metastases).Endocrine therapy was limited to traditional medical castration therapy(excluding novel endocrine agents such as abiraterone).Chinese and English databases were searched(up to March 1,2025)to include clinical studies comparing RP combined with endocrine therapy(combined treatment group)and endocrine therapy alone(single treatment group)for OmPCa.Meta-analysis was performed using RevMan 5.4 software,and hazard ratios(HR)with 95%confidence intervals(CI)were calculated.Results A total of 13 studies involving 1,120 patients were included.The results of Meta-analysis showed that the combined treatment group was significantly superior to the single treatment group in terms of radiologic progression-free survival(rPFS,HR=0.41,95%CI:0.30-0.55,P<0.00001),castration-resistant progression-free survival(CRFS,HR=0.57,95%CI:0.47-0.70,P<0.00001),cancer-specific survival(CSS,HR=0.41,95%CI:0.31-0.55,P<0.00001),overall survival(OS,HR=0.53,95%CI:0.37-0.75,P=0.0004),and complication rate(RD=-0.23,95%CI:-0.32--0.14,P<0.00001).No significant het-erogeneity was observed for all outcomes(I²<50%).Conclusion RP combined with endocrine therapy can improve the prognosis of patients with OmPCa,but clinical decisions still need to comprehensively evaluate the individual characteristics of patients and surgical risks.
Keywords：prostate canceroligometastasisradical prostatectomyendocrine therapyMeta-analysis
Publication Date：2025-12-28
Online Publishing Date：2026-03-11(First online date of this platform, not the publication date of the document)
Pages：9( 407-415 )