Observation on Clinical Efficacy of Laparoscopic-assisted Nerve-Sparing Radical Prostatectomy(LabNSRP)versus Laparoscopic Radical Prostatectomy(LRP)in the Treatment of Prostate Cancer
Lei Chao
Fan Dibing
Dong Wenrui
Chen Yanjun
Jia Shaomao
Abstract：Objective:To explore the clinical efficacy of laparoscopic-assisted nerve-sparing radical prostatectomy(LabNSRP)versus laparoscopic radical prostatectomy(LRP)in the treatment of prostate cancer.Methods:A prospective study was conducted on 216 patients with prostate cancer admitted to Guangyuan First People's Hospital from January 2019 to March 2023.They were divided into a study group and a control group according to the random number table method,with 108 cases in each group.The control group was treated with LRP,and the study group was treated with LabNSRP.The periop-erative indicators,serum tumor markers[carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),prostatic acid phosphatase(PAP),total prostate-specific antigen(TPSA),free prostate-specific antigen(FPSA)],immune function indi-cators(CD3+,CD4+,CD4+/CD8+),prognosis-related markers[granulin 88(GP88),phosphoglycerate kinase 1(PGK-1),α-methylacyl-CoA racemase(AMACR),platelet-to-lymphocyte ratio(PLR)],International Prostate Symptom Score(IPSS),Quality of Life Score(QOL),International Index of Erectile Function-5(IIEF-5)score,and postoperative compli-cations were compared between the two groups.The patients were followed up for 12 months,and the recurrence rates of the two groups were statistically compared.Results:The intestinal function recovery time in the study group[(2.39±0.76)days]was shorter than that in the control group[(3.24±0.88)days],and the difference was statistically significant(P<0.05).There were no statistically significant differences in operation time,positive surgical margin rate,blood loss,postoper-ative drainage volume,or length of hospital stay between the two groups(P>0.05).On the 3rd day after surgery,the levels of CD3+,CD4+,and CD4+/CD8+in the study group were higher than those in the control group(P<0.05).There were no statistically significant differences in peripheral blood PLR and serum levels of AMACR,GP88,PGK-1,PAP,CEA,TP-SA,and NSE between the two groups at 1 month after surgery(P>0.05).At 3 months after surgery,the IPSS score in the study group was lower than that in the control group,while the IIEF-5 and QOL scores were higher than those in the control group(P<0.05).Within 3 months after surgery,the incidence of complications in the study group was lower than that in the control group(P<0.05).There was no statistically significant difference in the recurrence rate between the two groups(P>0.05).Conclusion:LabNSRP in the treatment of prostate cancer can effectively promote the recovery of postoperative uri-nary control and erectile function,reduce postoperative immune dysfunction,lower the risk of postoperative complications,and improve the quality of life.
Keywords：laparoscopyradical prostatectomytumor markersimmune functionerectile functioncomplications
Publication Date：2025-08-28
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：7( 256-262 )