Application Value of Dual-source CT in Differentiating Pediatric Urinary Tract Stones:An in Vitro Experiment
Liu Yongxiang
Ainiwaer·Yusufu
Zhang Peixin
Lei Peng
Liu Bide
Li Jiuzhi
Du Weili
Tang Qin
Liu Dong
Yeerfan·Aierken
Jia Hongliang
Abstract：Objective:To investigate the value of dual-source CT multi-parameters in identifying the composi-tion of ammonium urate,uric acid,and calcium oxalate stones in children.Methods:A retrospective analysis was conducted on 78 pediatric patients with urinary tract stones who met the inclusion criteria and were treated at People's Hospital of Xinjiang Uygur Autonomous Region and Children's Hospital of Xinjiang Uygur Autonomous Region from January 2018 to June 2023.After surgery,stones were removed and analyzed for composition using infrared spectros-copy.The stones were scanned using dual-source CT in an ex vivo model,and statistical analysis of the CT multi-pa-rameters was performed.Results:A total of 78 stones were included in the study.Among them,29(37％)were am-monium urate stones,41(53％)were calcium oxalate stones,and 8(10％)were uric acid stones.Comparisons be-tween the ammonium urate group and the uric acid group showed statistically significant differences in mixed energy CT values,CT values(140 kV),dual-energy differences,dual-energy ratios,and dual-energy index values(all P＜0.05).When comparing the calcium oxalate group with the ammonium urate and uric acid groups,significant differ-ences were found in mixed energy CT values,CT values(100 kV),CT values(140 kV),dual-energy differences,dual-energy ratios,and dual-energy index values(P＜0.001 or P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that CT values(140 kV)were most effective in differentiating ammonium urate and uric acid stones,while dual-energy difference and dual-energy index were most effective in distinguishing ammonium urate and calcium oxalate stones.Dual-energy difference,dual-energy ratio,and dual-energy index were most effective in differ-entiating uric acid and calcium oxalate stones.Conclusion:Pediatric urinary tract stones are primarily composed of calcium oxalate and ammonium urate.Preoperative dual-source CT scanning helps to differentiate ammonium urate,uric acid,and calcium oxalate stones,providing valuable support for personalized treatment in pediatric patients with urinary tract stones..
Keywords：dual-source CTurinary tract stonesammonium uratestone compositionchildren
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 84-90 )