Effects of Prostatic Urethral Suspension on Lower Urinary Tract Function,Serum Inflammatory Stress Factors and Complications in Small-volume Benign Prostatic Hyperplasia Patients
Li Zhengping
Li Yongfen
Wang Shengpeng
Abstract：Objective:To investigate the impact of prostatic urethral suspension(PUL)on lower urinary tract function,serum inflammatory-stress markers,and complications in patients with small-volume benign prostatic hyper-plasia(BPH).Methods:A total of 116 patients with small-volume BPH treated at the Fourth People's Hospital of Qinghai Province from August 2022 to August 2023 were enrolled and randomly divided into the control group(58 cases)and the study group(58 cases).The control group received transurethral resection of the prostate(TURP),while the study group underwent PUL treatment.Perioperative data,serum inflammatory-stress factors[lipid peroxi-dation(LPO),malondialdehyde(MDA),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],lower urinary tract function[postvoid residual urine(PVR),maximum urinary flow rate(Qmax),maximum bladder contraction pres-sure(Pdetmax)],prostate-specific antigen(PSA)levels[free PSA(fPSA),total PSA(tPSA)],prostate symp-toms(International Prostate Symptom Score(IPSS)),erectile function(International Index of Erectile Function-5(IIEF-5)),quality of life(Quality of Life(QOL)score),and postoperative complications were compared between the two groups.Statistical analysis was performed using t-tests and chi-square tests.Results:The study group had shorter surgery duration,catheterization time,bladder irrigation time,and hospital stay compared to the control group(P<0.05).Three days after surgery,the study group had lower serum IL-6,TNF-α,LPO,and MDA levels than the control group(P<0.05).There were no significant differences in serum tPSA and fPSA levels between the two groups before surgery and at 6 months postoperatively(P>0.05).At 6 months postoperatively,the study group had lower PVR,higher Qmax and Pdetmax,and lower IPSS and QOL scores compared to the control group(P<0.05),while no significant difference in IIEF-5 scores was found between the two groups(P>0.05).The total incidence of postoperative complications in the study group was lower than that in the control group(P<0.05).Conclusion:Com-pared to TURP,PUL offers shorter surgery time,smaller trauma,faster recovery,and fewer complications for pa-tients with small-volume BPH.It can effectively improve lower urinary tract function,prostate symptoms,and quali-ty of life.
Keywords：benign prostatic hyperplasiaprostatic urethral suspensiontransurethral resection of the prostatelower urinary tract functionprostate-specific antigencomplication
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 31-37 )