Clinical efficacy analysis of repeat transurethral resection after thulium laser en bloc resection for non-muscle invasive bladder cancer

Zhu Dawei; Yuan Fang; Wang Cheng; Liu Nan; Yuan Gangjun

doi:10.19558/j.cnki.10-1020/r.2024.06.005

Abstract：Objective:To investigate the efficacy of secondary transurethral resection in the treatment of non-muscle invasive bladder cancer(NMIBC)after transurethral thulium laser en bloc resection of bladder tumors(Tm-LERBT).Methods:A retrospective analysis was conducted on the clinical and pathological data of 98 NMIBC pa-tients who underwent TmLERBT at Chongqing University Cancer Hospital from August 2020 to April 2023.Based on whether the patients underwent secondary transurethral resection,they were divided into Group A(43 cases)and Group B(55 cases).Patients in Group A received secondary transurethral resection after TmLERBT,while those in Group B did not.The recurrence and progression rates between the two groups were compared,and the clinical signif-icance of secondary transurethral resection after TmLERBT for disease control in NMIBC patients was analyzed.Re-sults:The average follow-up period was(27.53±10.57)months for Group A and(24.47±11.73)months for Group B.There was no significant difference in the follow-up duration between the two groups(P=0.184).During the follow-up period,the recurrence rate in Group A was 16.3%(7/43),and the progression rate was 4.7%(2/43).In Group B,the recurrence rate was 21.8%(12/55),and the progression rate was 7.3%(4/55).There were no sta-tistically significant differences in recurrence and progression rates between the two groups(P=0.491 and P=0.910,respectively).Conclusion:Short-term follow-up results suggest that secondary transurethral resection after TmLERBT does not reduce the risk of tumor recurrence or progression in NMIBC patients.The TmLERBT tech-nique may be an effective method to avoid the secondary transurethral resection.