The value of preoperative serum uric acid and its nomogram model in the prognosis of patients undergoing radical cystectomy

Wei Weiyang; Yang Hao; Zhou Chuanpeng; Wang Qi; Huang Hongxing; Huang Yaqiang

doi:10.19558/j.cnki.10-1020/r.2024.05.008

Abstract：Objective:To investigate the relationship between preoperative serum uric acid(SUA)level and overall survival(OS)of patients undergoing radical cystectomy(RC),and to construct a nomogram for predicting the OS rate of RC patients.Methods:The clinical data of 112 patients who underwent RC in the Department of Urol-ogy of Zhongshan City People's Hospital from July 2013 to December 2020 and met the eligibility criteria were collect-ed.The optimal cut-off value of preoperative SUA was calculated using the receiver operator characteristic(ROC)curve and divided into high and low SUA groups.Independent risk factors affecting OS in RC patients were screened by Cox regression,and a nomogram model was constructed.Results:The optimal cut-off value of SUA was 373 μmol/L.The postoperative OS of patients in the low SUA group was significantly better than that in the high SUA group(P<0.01),and there were significantly statistical differences between the two groups in terms of T stage,path-ological grading,tumor size,and survival(P<0.05).T stage,pathological grading,tumor number,tumor size,and preoperative SUA were independent risk factors affecting the OS of RC patients(P<0.05).Internal validation of the nomogram model evidence confirmed that the model had good discrimination,accuracy and clinical benefit.Conclu-sion:Preoperative SUA can independently affect the OS of RC patients,and the nomogram constructed on the basis of SUA has a certain predictive value for the OS rate of RC patients,which can provide a reference for the early post-operative adjuvant treatment of patients and the development of follow-up programs.