Correlation between serum levels of CTGF and FN1 and prognosis in patients with benign prostatic hyperplasia
Sun Yu
Ren Yu
Yu Song
LiuJunqiang
He Xiang
Abstract：Objective:To investigate the relationship between level of serum connective tissue growth factor(CTGF)and fibronectin 1(FN1)and prognosis of patients with benign prostatic hyperplasia.Methods:Eighty pa-tients benign prostatic hyperplasia patients who accepted transurethral bipolar plasma kinetic prostatectomy(TUPKP)from January 2020 to September 2021 in our hospital were retrospectively analyzed.They were divided in-to favorable prognosis group(n=56)and bad prognosis group(n=24)according to their prognosis.The general da-tas,serum levels of CTGF and FN1,urodynamic parameters[maximum urinary flow rate(Qmax)],maximum uri-nary closure pressure(MUCP),residual urine volume(RUV),bladder compliance(BC)preoperative and postopera-tive 7 d were compared between the two groups.The predictive value of serum levels of CTGF and FN1 for the prog-nosis of benign prostatic hyperplasia was analyzed.Results:The levels of serum CTGF,FN1 and PSA in bad prog-nosis group were obviously higher than that of favorable prognosis group at 7 days after operation(P＜0.05).The pro-portion of preoperative catheterization,≥90 minutes surgical time and≥7 days catheter indwelling and IPSS score in bad prognosis group were higher than those of favorable prognosis group(P＜0.05).Pearson correlation analysis showed that there was obvious positive correlation between serum level of CTGF,FN1 and PSA in benign prostatic hyperplasia(r=0.432,r=0.376,P＜0.001).Serum leve of lCTGF was positively correlated with the level of FN1(r =0.538,P＜0.001).Multivariate logistic regression analysis showed that serum of CTGF,FN1,PSA,preoperative catheterization,surgical time,postoperative catheter indwelling time,IPSS score were influencing factors for bad prognosis of benign prostatic hyperplasia(P＜0.05).The AUC of serum CTGF and FN1 for combined predicting prognosis of benign prostatic hyperplasia was 0.974,the sensitivity was 91.67%,and the specificity was 94.64%,which was superior to single prediction(Z=1.968,P=0.042;Z=2.185,P=0.029).Conclusion:The serum levels of CTGF and FN1 at 7 days after operation in bad prognosis group were higher than those of favorable prognosis group,combined detection of the two can better evaluate prognosis of benign prostatic hyperplasia.
Keywords：prostatic hyperplasiaconnective tissue growth factorfibronectin 1prognosis
Publication Date：2023-12-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 379-384 )