The effect of endoscopic mucosal dissection of transurethral bladder tumor on circulating tumor cells in patients
Wang Zhigang
Duan Wanli
Guan Zhenfeng
Liang Liang
Cheng Yongyi
SunYi
Abstract：Objective:To investigate the effect of transurethral bladder tumor endoscopic mucosal dissection on the number of circulating tumor cells(CTCs)in patients.Methods:Collected patients(19 cases)of transurethral bladder tumor-endoscopic submucosal dissection(BT-ESD)and conventional transurethral resection of bladder tu-mor(cTURBT)(19 cases).Peripheral venous blood samples were collected before and during the operation.Cyttel-TM-CTC platform detection technology(negative enrichment technology combined with immunofluorescence in situ hybridization)was performed to analyze the CTCs number in the peripheral blood of the patients.CTCs number were compared before and post operation during the BT-ESD and cTURBT groups.Results:There was no significant dif-ference in the peripheral blood circulating tumor cell counts in the BT-ESD group before and after surgery(P= 0.712);The peripheral blood circulating tumor cell counts in the cTURBT group were significantly higher than that in cTURBT group(P<0.001)and BT-ESD group(P<0.001)before surgery(P<0.001);The postoperative CTCs number and perioperative CTCs number change were significantly correlated with bladder tumor recurrent in the cTURBT group(P=0.002,P=0.001).Conclusion:Transurethral bladder tumors endoscopic submucosal dissec-tion approach does not increase the perioperative CTCs number.
Keywords：transurethral bladder tumor endoscopic mucosal dissectiontransurethral resection of bladder tumorcir-culating tumor cellsnon-muscular invasive bladder cancer
Publication Date：2023-10-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 305-310 )