Influencing factors of tumor-free survival after radical resection of upper urinary tract urothelial carcinoma

Guo Liangfang; Yang Qiuxiang; Liu Yan

doi:10.19558/j.cnki.10-1020/r.2018.03.015

Abstract：Objective:To investigate the influencing factors of tumor-free survival after radical resection of up-per urinary tract urothelial carcinoma.Methods:730 patients with upper urinary tract urothelial carcinomas who were admitted to our hospital from March 2012 to March 2014 were selected as the subjects,and all patients were treated by radical resection.The clinical and pathological data of the patients were collected,and the patients were followed up for 3 years after operation.The occurrence of recurrence or death found by imaging examination was taken as the endpoint of tumor-free survival,and the tumor-free survival rate within 3 years was statistically ana-lyzed.Results:In the 730 patients,702 were followed up effectively,including 69 death cases,101 recurrent cases and 532 tumor-free survival cases,and the 3-year tumor-free survival rate was 75.8% (532/702).The proportions of patients who were or older than 60 years old,who were female,whose tumor diameter was or longer than 3 cm,who had 2 or more than 2 tumors,who had tumors at TNM stage Ⅲ-Ⅳ,high WHO grade and who had hy-dronephrosis in the tumor-free survival ≥ 3 years group was significantly lower than those in the tumor-free sur-vival <3 years group (P<0.05).No significant differences were found in the affected side,tumor location or lymph node dissection between the two groups (P>0.05).Logistic regression analysis showed that tumor stage, differentiation degree and hydronephrosis were independent influencing factors of tumor-free survival after radical resection of upper urinary tract urothelial carcinoma.Conclusions:Age,gender,the diameter and number of tumors,TNM stage,WHO grading and hydronephrosis have significant influence on the tumor-free survival after radical resection of upper urinary tract urothelial carcinoma.