Clinical effectiveness of immediate intravesical instillation of second resection combined with pirarubicin in the treatment of non-muscular invasive bladder urothelial carcinoma
Bai Daying
Liu Jie
Wang Yunjie
Li Zhushi
Zhang Zhongjun
Abstract：Objective:To evaluate the clinical efficacy of immediate intravesical instillation of second resection combined with pirarubicin in the treatment of non-muscular invasive bladder carcinoma(NMIBC).Methods:Sixty-three cases of NMIBC from Jan.2010 to May 2014 were reviewed.The patients who received second resection of transurethral resection of bladder tumor(TURBT)served as treatment group(35 cases),and the rest 28 cases given only one resection as control group.All of the patients were treated with immediate intravesical instillation with pirarubicin.Recurrence and progression between the two groups were observed at 6th,12th,18th and 24th month.Results:At 6th,12th,18th and 24th month,the recurrence rate and the progression rate had statistically significant difference between treatment group and control group(P<0.01)(for control group:10.7% and 0, 17.9% and 3.6%,28.6% and 10.7%,and 46.4% and 21.4% respectively;for treatment group:2.9% and 0, 2.9% and 0,8.6% and 2.9%,and 14.3% and 5.7% respectively).Conclusions:Immediate intravesical instillation of pirarubicin after TURBT can significantly can significantly reduce the relapse of NMIBC.Second resection was effective for removing the remnant tumors of NMIBC and also helped clinicians choose the right treatment strategies and im-prove the survival of patients with NMIBC.
Keywords：second resectionnon-muscle invasive bladder urothelial carcinomaneoplasm recurrencelocalimmediate intravesical instillationpirarubicin
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 61-64 )