Relationship between neutrophil/lymphocyte ratio and prognosis of non-muscular invasive bladder cancer
Wang Jukun
Shang Zhenhua
Cui Bo
Wang Xu
Yan Hao
Wang Qi
Cui Xin
Li Jin
Jia Chunsong
Ou Tongwen
Abstract：Objective:To investigate the relationship between preoperative neutrophil to lymphocyte ratio (NLR)and prognosis in non-muscle invasive bladder cancer(NMIBC)patients undergoing transurethral resection of bladder tumor(TURBT).Methods:We retrospectively collected data of 472 eligible patients who were diag-nosed as having NMIBC and received TURBT between January 2003 and December 2011.The association of NLR with clinicopathological characteristics was further analyzed by dichotomizing our sample into those with NLR ≤2.32(low NLR group)and those with NLR>2.32(high NLR group),based on the receiver operating character-istic curve(ROC)analysis.Overall survival(OS)and cancer specific survival(CSS)were estimated by Kaplan-Meier analysis,and the log-rank test was used to compare differences between groups.Univariate and multivariate Cox regression analyses were plotted to assess the prognostic value of NLR in NMIBC patients.Results:The medi-an OS was 82.0 months in the low NLR group,and 67.0 months in the high NLR group(OS:P=0.004).Kap-lan-Meier survival analysis revealed that lower NLR was significantly correlated with greater OS and greater CSS.NLR was shown to be an independent predictor for OS(hazard ratio[HR],1.877;95% confidence interval [CI],1.363-2.583;P<0.001)and CSS(hazard ratio[HR],13.820;95% confidence interval[CI],3.45 to 60.730;P<0.001).Conclusions:NLR ≤ 2.32 was independently associated with greater OS and CSS in patients with NMIBC undergoing TURBT and may serve as a valuable prognostic factor for the therapeutic decision making.
Keywords：non-muscule invasive bladder cancerneutrophil/lymphocyte ratioprognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 55-60 )