Efficacy and safety of holmium laser versus conventional transurethral resection for non muscle invasive bladder cancer:a review and meta-analysis
Li Tao
Fu Chongde
Jiao Lin
Wei Qiaohong
Chen Guangyu
Tang Yao
Gao Hui
Xie Shengtao
Abstract：Objective:To systematically assess the efficacy and safety of holmium laser(HOLRBt)versus conventional transurethral resection(TURBT)for non muscle invasive bladder cancer(NMIBC).Methods:Ran-domized controlled trials(RCTs)regarding the efficacy and safety of HOLRBt vs.TURBT for NMIBC were re-trieved in PubMed,Cochrane library,Sciverse,CNKI,VIP and Wanfang database from databases establishment to Dec.2016.According to the including and exclusion criterion,two reviewers independently screened the trials, and the Meta-analysis was done with RevMan 5.3 soft ware.Results:A total of 14 RCTs were eligible for the study,including 1 746 cases.The pooled results showed that HOLRBt group had a less blood loss[MD = -66.00,95% CI=(80.75, -51.24),P< 0.000 01],and lower obturator reflex rate[RR= 0.06,95% CI=(0.02,0.16),P< 0.000 01]and perforation rate[RR= 0.15,95% CI=(0.07,0.33),P< 0.000 01]than TURBT group.However,there was no significant difference in operation time[MD= -0.14,95% CI=(-3.55,3.26),P=0.93]between two groups.Meanwhile,the one-year recurrence rate in HOLRBt group was sig-nificantly lower than that in TURBT group[RR=0.65,95% CI=(0.46,0.91),P=0.01].There was no sig-nificant difference in the 2-year recurrence rate between two groups[RR=0.52,95% CI=(0.20,1.37),P=0.19].Conclusions:Compared with TURBT,HOLRBt had less blood loss and lower obturator reflex rate and perforation rate.Therefore,HOLRBt should be considered as a preferable option for NMIBC.
Keywords：non-muscle-invasive bladder canerholmium laser transurethral resectiontransurethral resection of bladder cancermeta analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 34-40 )