Use of botulinum toxin in the treatment of detrusor external sphincter dyssynergia
Shang Zhenhua
Yan Hao
Jia Chunsong
Cui Bo
Gao Wei
Wang Xu
Wang Jukun
Wang Qi
Cui Xin
Ou Tongwen
Abstract：Detrusor external sphincter dyssynergia (DESD) is common urodynamic findings in patients with suprasacral spinal cord injury,and multiple sclerosis.Patients' quality of life is impacted severely if the condition is not treated appropriately.As a common neurotoxin,botulinum toxin works through inhibiting vesicular neurotransmitter release at the neuromuscular and neuroglandular junctions.External sphincter injections of botulinum toxin were of short-term efficacy by relaxing external sphincter passively.However,efficacy may be affected by pathophysiology of disease states,or the sex distribution of patients.In this study we review the mechanism,safety,efficacy and side effects of botulinum toxin in treating detrusor external sphincter dyssynergia.
Keywords：botulinum toxindetrusor external sphincter dyssynergiaefficacy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 315-320 )