Related factors of recurrence of clear cell renal cell carcinoma after partial nephrectomy
Fan Yang
Wang Yunpeng
Ma Xin
Li Hongzhao
Chen Guangfu
Guo Gang
Zhu Qiang
Gao Yu
Huang Qingbo
Ai Qing
Su Hanxing
Zhang Xu
Abstract：Objective:To explore the related risk factors of recurrence and metastasis of clear cell renal cell carcinoma (ccRCC) after partial nephrectomy (PN).Methods:We retrospectively analyzed the clinicopathological data and follow-up results of 1 742 sporadic unilateral ccRCC patients who underwent PN in Urology Department of PLA General Hospital from January 2006 to December 2015,and the related factors of post-operative recurrence and metastasis were obtained by univariate and multivariate analysis.Results:The patients were followed up for 3.1-120.7 months with the median follow-up time of 32.4 months (mean 36.3 months).Thirty-three patients had recurrence (1.9%).Univariate analysis showed that Fuhrman grade (HR=4.476,95% CI=1.717-11.672,P=0.002),tumor necrosis (HR=5.728,95% CI=2.478-13.241,P<0.001) and sarcomatoid differenciation (HR=29.636,95% CI=3.991-220.062,P=0.001) had significant effects on the recurrence-free survival of ccRCC patients after PN.Multivariate analysis also revealed that Fuhrman grade (HR=3.223,95% CI=1.161-8.946,P=0.025),tumor necrosis (HR=5.150,95% CI=2.195-12.081,P<0.001) and sarcomatoid differenciation (HR=16.321,95% CI=1.973-134.992,P=0.01) were independent factors of recurrence-free survival of ccRCC patients after PN.Conclusions:Fuhrman grade,tumor necrosis,and sarcomatoid differenciation are related risk factors for recurrence of ccRCC patients after PN.
Keywords：clear cell renal cell carcinomapartial nephrectomyrecurrence
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 216-220 )