Clinical effect of transurethral resection of bladder tumor combined with internal iliac artery chemotherapy for muscle invasive bladder cancer
Wang Qi
Xu Jiawei
Ou Tongwen
Xu Jianjun
Li Jin
Cui Xin
Abstract：Objective:To evaluate the clinical effect of transurethral resection (TUR)of bladder tumor combined with internal iliac artery chemotherapy with or without intravesical instillation therapy for muscle invasive bladder cancer (MI-BC).Methods:Seventy-one patients with MIBC were selected and treated with TUR of bladder tumor combined with in-travesical instillation therapy,with or without internal iliac artery chemotherapy (chemotherapy regimen:gemcitabine and cisplatin,GC)between February 2007 to June 2014.The bladder preservation and survival rate as well as cancer specific survival rate (CSS)and overall survival rate (OS)of the two groups were compared.Results:Seventy-one patients were followed up for 18-100 months with an average of 59 months.The two-year bladder preserved rate in TUR+GC group and TUR group was 92.9% and 79.3%,respectively (P<0.05).The one-year DFS in TUR+GC group and TUR group was 83.3% and 58.6%,and the 2-year DFS was 78.6% and 62.1% for 2 years,respectively (P<0.05).The 2-year cancer CSS in TUR+GC group and TUR group was 92.9% and 82.8%,respectively (P>0.05).The 2-year OS in TUR+GC group and TUR group was 88.1% and 82.8%,respectively (P>0.05).Conclusions:TURBT and intra-vesical instillation therapy combine with internal iliac artery chemotherapy for MIBC may have better outcome at recur-rence-free survival,bladder preserved rate,DFS than the treatment without internal iliac artery chemotherapy,and there was no difference in OS and CSS.
Keywords：transurethral resectioninternal artery chemotherapybladder cancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 229-232 )