Cool-ti p radiofrequency ablation for renal cell carci no ma in vitro
Chen Guangfu
Wang Xiyou
Liu Aijun
Sun Shengkun
Zhu Jie
Chen Wenzheng
Zhang Xu
Abstract：Objective :To i nvesti gate the i nfl uence of radi ofrequency ablati on on the ablati on necrosis range ,for m and surroundi ng tissue of hu man vitro ki dney carci no ma ,i n order to provi de theoretical basis for cli nical applicati on . Methods :1 2 cases of ki dney of renal cell carci no ma patients by laparoscopic retroperitoneal radical nephrecto my (the maxi mu m dia meter of tu mor ≤3.2 c m),which were rando ml y di vi ded i nto 5 mi n nor mal ki dney group (group A, 1 2 cases /ti mes ),5 mi n renal carci no ma group (group B ,6 cases /ti mes ),1 2 mi n nor mal ki dney group (group C , 1 2 cases )and 1 2 mi n renal carci no ma group (group D ,6 cases /ti mes ).After the speci mens bei ng sent to Pathol ogy Depart ment ,we gave the m radi ofrequency ablati ons for different ti me ,observed the state duri ng radi ofre quency ablati on ,ablati on necrosis range of nor mal ki dney tissue and tu mor tissue and the i ntegrity of collecti on syste m by macroscopic observati on .Then made the pathol ogical slices and observed the pathol ogical chan-ges of the ablati on issue .Results :①The outer surface te mperature of the tissue rises duri ng radi ofrequency ablati on , tissue shri nks ,si nks ,and there are hot bubbles overfl o wi ng al ong the needle track ;②The patterns of nor mal ki dney tissue radi ofrequency ablati on lesi on is the elli psoi dal around RF needle ,l ong axis parallels to RF needle ,the ki dney tu mor tissue ablati on lesi on less than 3.2 c mis the ori gi nal shape of tu mor morphol ogy ,the capsule for mati on obvi-ous boundary of tu mor and nor mal ki dney tissue ;③Co mpared with group C ,radi ofrequency ablati on range of group A decreased si gnificantl y (P <0.01 ).The ablati on range of group B is not consistent ,less than 2 c mi n dia meter of tu mor ablati on maxi mu mtu mor dia meter ,tu mor ablati on dia meter greater than 2 c m,the ablati on dia meter of group D is the maxi mal tu mor dia meter ;④There are 2 cases of collecti on syste mi nj ury ,which are observed i n the ki dney of needle ti p cl ose to collecti on syste m of less than 5 mm.Conclusions :5 mi nutes of radi ofrequency ablati on cannot ensure co mpletel y ablate the tu mors wich are less than 3.2 c m,1 2 mi nutes of ablati on is suitable for the tu mor with the maxi mu m dia meter of less than 3.2 c m;when co mplete capsule ,for mi ng the "pressure cooker"effect ,less than 3.2 c m of the tu mors can be any angle needle ;when i nco mplete capsule ,ensure the RF needle and tu mor axis over-lap as far as possi ble ,such as renal ventral or central tu mor ,laparoscopic radi ofrequency ablati on may be more ap-propriate ;when the tu mor is cl ose to collecti on syste m,it may be da maged ,the collecti on syste m col d perfusi on can be used to protect it ;if the tu mor is adj acent to the organs such as bo wel ,spleen ,laparoscopic surgery may be safer .
Keywords：radi ofrequency ablati onlaparoscopyrenal cell carci no ma
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 65-70 )