DOI: 10.11958/20252966
The predictive value of lipoprotein-associated phospholipase A2 combined with the total burden of MRI scores on cognitive impairment in patients with cerebral small vessel disease
REN Baolong
JIAO Aiju
ZHU Ruolan
ZHAO Weijing
Abstract：Objective To investigate the predictive value of lipoprotein-associated phospholipase A2(Lp-PLA2)combined with the total burden of magnetic resonance imaging(MRI)scores on cognitive impairment in patients with cerebral small vessel disease(CSVD).Methods A total of 178 CSVD patients admitted to Gansu Wuwei Tumour Hospital(Gansu Province Wuwei Academy of Medical Sciences)from January 2023 to June 2024 were divided into the normal cognition group(n=89,MoCA≥26)and the cognitive impairment group(n=89,MoCA＜26 points).The CSVD total burden of MRI scores was evaluated by 3.0T MRI.The baseline data,Lp-PLA2 level and the total burden of MRI scores were compared between the two groups.Logistic regression was applied to analyze influencing factors of cognitive impairment in CSVD patients.The predictive value of Lp-PLA2 level combined with the total burden of MRI scores on cognitive impairment in CSVD patients were analyzed by receiver operating characteristic(ROC)curve.Results Compared with the normal cognition group,Lp-PLA2 levels,the total burden of MRI scores and IL-6 were significantly increased in the cognitive impairment group(P＜0.05).Results of multivariate Logistic regression analysis showed that increased Lp-PLA2 and the total burden of MRI scores were risk factors for cognitive impairment in patients with CSVD(P＜0.05).The area under curve(AUC)of Lp-PLA2 levels combined with the total burden of MRI scores for predicting cognitive impairment in patients with CSVD was 0.905(95%CI:0.861-0.948),the sensitivity was 86.5%and the specificity was 79.8%.Conclusion Lp-PLA2 levels and the total burden of MRI scores are increased in patients with cognitive impairment,and the combination of both can serve as an early predictor of cognitive impairment in patients with CSVD.
Keywords：cerebral small vessel diseasescognition disorders1-alkyl-2-acetylglycerophosphocholine esteraselipoprotein-associated phospholipase A2the total burden of MRI scores
Publication Date：2026-03-15
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：4( 245-248 )