Analysis of the therapeutic effect of Wuzhuyu decoction combined with dolasetron mesylate in the treatment of chemotherapy-induced vomiting

FENG Hao; GUO Xiaoshuang; REN Xiaojing; LI Ming

doi:10.11958/20252748

Abstract：Objective To investigate the effect of evodia delavonium decoction combined with dolasetron mesylate on the efficacy in patients of chemotherapy-induced vomiting.Methods A total of 116 patients with chemotherapy-induced vomiting admitted to our hospital from June 2023 to January 2025 were enrolled.Patients were divided into two groups with 58 cases in each group.The control group was treated with dolasetron mesylate for antiemetic,and the observation group was supplemented with evodia decoction on the basis of it.The treatment effects including complete remission rate and complete control rate of patients in the acute stage,delayed period and whole course of treatment were counted,and the degree of vomiting after treatment was evaluated.Serotonin(5-HT),immune function indicators,and liver and kidney function indicators before and after treatment were evaluated.Results Compared with the control group,the observation group showed an increased complete relief rate and complete control rate during the delayed phase and throughout the treatment(P＜0.05).There was significant difference in the degree of vomiting between the two groups(P＜0.05).Compared with the control group,5-HT levels decreased in the delayed phase of the observation group(P＜0.05).Compared with the control group,the levels of immunoglobulin A,immunoglobulin M and immunoglobulin G increased after treatment in the observation group(P＜0.05).There were no significant differences in blood urea nitrogen,creatinine,alanine aminotransferase and aspartate aminotransferase before and after treatment between both groups(P＞0.05),and there were no significant differences in these indicators between the two groups(P＞0.05).Conclusion Wuzhuyu decoction combined with dexamethasone can effectively relieve chemotherapy-induced vomiting,reduce the severity of vomiting and 5-HT levels,improve humoral immunity,and is safe and effective.