DOI: 10.11958/20252509
New advances in research on amino acid metabolism regulation in ovarian aging
WU Die
DING Lijun
Abstract：The core characteristics of ovarian aging are the depletion of ovarian follicle reserve and the decline in oocyte quality.In recent years,disordered amino acid metabolism has been confirmed to be closely associated with the process of ovarian aging.This article provides a systematic review of the role of amino acid metabolic network in ovarian aging.It encompasses various aging-related metabolic alterations,including dysregulated branched-chain amino acid(BCAA)metabolism,increased glutamine dependency coupled with reduced metabolic efficiency,impaired one-carbon metabolism,disturbances in the arginine-nitric oxide-polyamine axis and changes in taurine levels.These metabolic changes impair follicular development,granulosa cell function and oocyte quality through multiple mechanisms.This review not only offers a new perspective for understanding the pathological mechanisms of ovarian aging but also provides a crucial theoretical foundation for developing innovative strategies—such as nutritional interventions or targeted regulation of amino acid metabolism—to delay ovarian aging and improve female fertility potential.
Keywords：ovaryagingoocytesamino acidsepigenomicsgranulosa cellsamino acid metabolism
Publication Date：2026-02-15
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：6( 139-144 )