DOI: 10.11958/20252447
Research progress of biological functions of miR-101-3p in cardiovascular diseases
PANG Zhihua
LIU Limei
YAO Zhuhua
Abstract：miR-101-3p is an evolutionarily conserved non-coding RNA that has shown aberrant expression and regulatory functios in various cardiovascular diseases(CVDs)in recent years.It participates in key pathological processes including post-infarction myocardial remodeling,myocardial fibrosis in heart failure and the development of atherosclerosis by modulating pathways such as apoptosis,autophagy and metabolism.In addition,it exhibits immunoregulatory potential in myocardium injury related to systemic diseases.This review summarizes the recent advances in understanding the role of miR-101-3p in CVDs,focusing on its expression dynamics and regulatory mechanisms in different disease models.It further elaborates on the biological effects of miR-101-3p in cardiovascular pathology and explores its potential as a diagnostic biomarker and therapeutic target.miR-101-3p is expected to provide novel insights for early detection and targeted intervention of cardiovascular diseases.
Keywords：myocardial infarctionheart failureatherosclerosismiR-101-3pmyocardial fibrosis
Publication Date：2025-11-15
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：5( 1223-1227 )