DOI: 10.11958/20251929
A case study on multidisciplinary support in comprehensive diagnosis and treatment of combined small cell lung cancer and exploration of MRD
LIU Chang
MENG Fanlu
YANG Jing
ZHANG Rongxin
WANG Junping
XIONG Jianhua
ZHONG Diansheng
Abstract：Combined small cell lung cancer(C-SCLC)accounts for approximately 20%of all SCLC cases,while the propotion of C-SCLC mixed with squamous cell carcinoma component comprises less than 3%.At the pathological level,accurate diagnosis requires to distinguish it from other lung tumor types,and even rely on molecular testing.This article presents a case of a 67-year-old patient initially diagnosed with a peripheral lung tumor.The patient underwent comprehensive multidisciplinary management,including surgical resection,postoperative pathological differential diagnosis,chemotherapy,thoracic radiotherapy,brain metastasis,cranial radiotherapy,dynamic follow-up of imaging changes after cranial radiotherapy,and cranial surgery.Molecular residual disease(MRD)monitoring was integrated at critical time points during dynamic monitoring to inform personalized treatment decisions.The early MDT has brought the patient′s condition under control,and the overall survival of the patient exceeded 30 months.Through the introduction of the diagnosis and treatment process of this patient,we aim to offer novel perspectives on clinical decision-making for C-SCLC.
Keywords：neoplasms by histologic typechemoradiotherapyneoplasmresidualcombined small cell lung cancerbrain metastasismulti-disciplinary treatment
Publication Date：2025-10-15
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：7( 1091-1097 )