DOI: 10.11958/20252016
Epidemiological analysis of high-risk HPV infection and genotype distribution in 13 105 women in Zhongguancun area,Beijing
YANG Yanyan
WANG Ping
YI Xue
PENG Jinzhu
HE Yu
ZHANG Wenyu
CHEN Lei
Aziya
Abstract：Objective To analyze the epidemiological characteristics of human papillomavirus(HPV)infection in women in the Zhongguancun area of Beijing,and to evaluate the infection rates and genotype distribution between different populations and age groups.Methods A retrospective analysis was conducted on HPV genotyping results of 13,105 women who visited the gynecology outpatient department or underwent routine health check-ups at Zhongguancun Hospital from March 2019 to April 2024.High-risk HPV genotypes(15 types)were detected using a fluorescence PCR assay.Positive cases were classified as single,dual or multiple(≥3)infections based on the number of genotypes.Subjects were stratified into six age groups(≤30,31-40,41-50,51-60,61-70,and≥71 years),and the characteristics of infection by type and age group were analyzed.Results The overall HPV positivity rate was 10.78%(1,413/13,105),with a significantly higher rate in the outpatient group than that in the health check-up group(16.36%vs.6.06%,P<0.01).The three most prevalent genotypes were HPV52(18.83%),HPV58(13.85%),and HPV16(11.28%).Single infections accounted for 79.19%of cases,dual infections for 15.93%and multiple infections for 4.88%.Age distribution showed a U-shaped pattern,with higher infection rate in women aged≤30 years(15.06%)and 61-70 years(13.19%),and the lowest rate in the≥71 years(8.09%).Notably,women aged≤30 years had the highest proportion of multiple infections(31.72%).Conclusion These findings provide a basis for cervical cancer screening strategies,HPV vaccination promotion and individualized prevention of cervical cancer in this region.
Keywords：papillomaviridaeuterine cervical neoplasmsepidemiologypapillomavirus vaccinesgenotypehuman papillomavirusZhongguancunmultiple infections
Publication Date：2025-10-15
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：5( 1086-1090 )