DOI: 10.11958/20251155
Research progress on the bidirectional relationship between sleep-related breathing disorders and pulmonary hypertension
DU Xintao
SUO Ying
ZHAO Xiaoyun
Abstract：Sleep-related breathing disorders(SBDs)are a group of disorders characterized by abnormal breathing patterns during sleep,with obstructive sleep apnea(OSA)being the most common type.Pulmonary hypertension(PH)is characterized pathophysiologically by pulmonary vasoconstriction and vascular remodeling,with initial clinical diagnosis typically relying on echocardiography.SBDs and PH have a bidirectional relationship in many aspects,with shared pathophysiological mechanisms such as hypoxia,inflammation and oxidative stress being common.The percentage of sleep time with nocturnal oxygen saturation＜0.90(T90)can assess the risk of pulmonary hemodynamic and right ventricular function deterioration in OSA patients,but this indicator still has limitation in clinical application.Currently,there is limited domestic research on the bidirectional relationship between SBDs and PH in China.This article reviews the bidirectional relationship between SBDs and PH in terms of epidemiology,potential mechanisms,screening and treatment.It also analyzes the relevance of OSA and PH based on current domestic and international clinical studies,providing a theoretical basis for further exploration of these two diseases.
Keywords：sleep apneaobstructivepulmonary arterial hypertensionsleep-related breathing disordersintermittent hypoxiahypoxic burdenglobal longitudinal strain
Publication Date：2025-08-15
Online Publishing Date：2025-08-20(First online date of this platform, not the publication date of the document)
Pages：8( 889-896 )