DOI: 10.11958/20242358
Prognostic value of PRMT2,TRAF2 and metastasis-related gene in renal clear cell carcinoma
DU Lingyun
WANG Yaowu
REN Nan
Abstract：Objective To analyze the correlation between expression levels of protein arginine methyltransferase 2(PRMT2),TNF receptor associated factor 2(TRAF2)and metastasis-related genes in clear cell renal cell carcinoma(ccRCC)and their evaluation value for prognosis.Methods A total of 110 patients with ccRCC were selected.The expression levels of PRMT2,TRAF2 protein and mRNA,and the expression of metastasis-related genes[N-cadherin(N-cad),E-cadherin(E-cad),vascular endothelial growth factor A(VEGFA),vascular endothelial growth factor C(VEGFC)]were detected in cancer tissue and paracancer tissue.Pearson correlation analysis was used to analyze the correlation between PRMT2,TRAF2 mRNA and metastasis-related genes,and the effect of PRMT2 and TRAF2 expression on the prognosis of ccRCC patients.Results The mRNA expression levels of PRMT2,TRAF2,N-cad,VEGFA and VEGFC were higher in ccRCC cancer tissue than those in adjacent tissue,and E-cad was lower in ccRCC cancer tissue than that in adjacent tissue(P＜0.01).PRMT2 and TRAF2 mRNA were positively correlated with N-cad,VEGFA and VEGFC mRNA expression,and negatively correlated with E-cad mRNA expression in cancer tissue(P＜0.01).The positive rates of PRMT2 protein and TRAF2 protein in ccRCC cancer tissue were higher than those in adjacent tissue(P＜0.01).The positive rates of PRMT2 and TRAF2 protein in TNM stage III cancer tissue were higher than those in TNM stage I-II cancer tissue(P＜0.05).The 3-year progression-free survival rate of the PRMT2 and TRAF2 positive group was lower than that of the negative group(P＜0.05).TNM stage III,PRMT2 positive and TRAF2 positive were risk factors affecting the progression-free survival prognosis of ccRCC patients(P＜0.05).Conclusion The expression levels of PRMT2 and TRAF2 are up-regulated in ccRCC,which are related to the expression of metastasis-related genes and TNM stage of tumor,and can be used as the marker for evaluating the prognosis of ccRCC.
Keywords：carcinomarenal cellprotein-arginine N-methyltransferasesTNF receptor-associated factor 2cadherinsvascular endothelial growth factorsprognosis
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 492-497 )