DOI: 10.11958/20250014
Multidisciplinary diagnostic and therapeutic analysis of a patient with heparin-induced thrombocytopenia
WANG Xin
ZHAO Xiaojing
DANG Lin
MEN Jianlong
Abstract：Heparin-induced thrombocytopenia(HIT)is an antibody-mediated adverse reaction to heparin that is clinically manifested as a progressive reduction in platelet count after heparin administration,leading to venous and/or arterial thromboembolism and even death in severe cases.Acquired thrombocytopenia is commonly observed in hospitalized patients,the pathological mechanism is associated with drugs,autoimmune diseases,and consumptive thrombocytopenia.Patients with HIT frequently have complex clinical situations,and their manifestations are often atypical or mixed with other symptoms and signs,posing significant challenges to diagnosis and treatment for clinicians.Through the multidisciplinary diagnosis and treatment process of a HIT patient,this paper discusses HIT occurrence mechanism,clinical evaluation,laboratory testing and alternative anticoagulant therapy,so as to provide reference for doctors to accurately identify and effectively intervention in clinical practice.
Keywords：heparinheparin-induced thrombocytopeniamulti-disciplinary treatment4Ts scoreanti-PF4/H antibodiesargatroban
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 194-198 )