DOI: 10.11958/20231289
Research progress of SIRT1 in the pathogenesis of diabetic cardiomyopathy
XIE Youcheng
WANG Fei
XU Jin
YU Xiaohui
Abstract：Diabetic cardiomyopathy(DCM)is one of the most serious cardiovascular complications in diabetic patients,and it is also the main cause of increased mortality in diabetic patients,which has become a major global public health problem.As an important intracellular regulatory protein in body,sirtuin 1(SIRT1)plays an important role in many biological processes,including reducing oxidative stress in cardiomyocytes,maintaining Ca2+ homeostasis in myocardial mitochondria,reducing myocardial endoplasmic reticulum stress,improving myocardial mitochondrial dysfunction,and inhibiting the activation of renin-angiotensin-aldosterone system.SIRT1 may be a potential therapeutic target for DCM.Further research targeting SIRT1 can provide a new theoretical basis for the clinical treatment of DCM.This article reviews the specific role of SIRT1 in the pathogenesis and treatment strategies of DCM.
Keywords：diabetes mellitusdiabetic cardiomyopathiessirtuin 1oxidative stressmitochondriaendoplasmic reticulum stressrenin-angiotensin-aldosterone system
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 443-448 )