DOI: 10.11958/20231309
Research progress on the role and mechanism of 5-hydroxytryptamine in gastrointestinal diseases
SHAN Zihong
HU Xiaoqing
LI Feng
HUANG Yongkun
Abstract：5-hydroxytryptamine(5-HT)is an important neurotransmitter in brain-gut axis pathway,and its secretion is closely related to intestinal flora,intestinal immunity and intestinal motility.Abnormal metabolic pathway of 5-HT is involved in the occurrence and development of gastrointestinal diseases,such as irritable bowel syndrome,inflammatory bowel disease,chronic constipation and functional dyspepsia.This article reviews the mechanism of 5-HT in different gastrointestinal diseases in order to explore new ideas for clinical treatment.
Keywords：serotonin5-hydroxytryptaminegastrointestinal diseasesintestinal floraintestinal motilityintestinal immunity
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 438-443 )