DOI: 10.11958/20231381
Research progress of cerebral organoid technology and its application in stroke treatment
SUN Kexin
XIAO Yuqian
WAN Jun
CHEN Shuying
CHEN Limin
WANG Yan
BAI Yanjie
Abstract：Cerebral organoids are three-dimensional nerve cultures induced by embryonic stem cells(ESCs)or induced pluripotent stem cells(iPSCs)that mimic the structure and function of human brain.With the continuous optimization of cerebral organoid culture technology and the combination with emerging technologies such as organ transplantation,gene editing and organoids-on-chip,complex brain tissue structures such as functional vascular structures and neural circuits have been produced,which provides new methods and ideas for studying human brain development and diseases.This article reviews the latest advances in brain organoid technology,describes its application in neurological diseases and advances in stroke modeling and transplantation treatment.
Keywords：organoidstransplantationmicrochip analytical proceduresstrokecerebral organoid
Publication Date：2024-01-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 38-43 )