Changes of PCSK9 level in patients with acute coronary syndrome and correlation analysis with LPS

ZHANG Xiu-ze; WANG Li

doi:10.11958/20161329

Abstract：Objective To explore the correlation between PCSK9 and LPS or lipoprotein in patients with acute coronary syndrome (ACS). Methods A total of 126 patients with coronary artery disease confirmed by coronary angiography were selected in our hospital from December 2015 to June 2016, including 65 patients with ACS and 61 patients with stable angina (SAP). And 49 patients without coronary heart disease confirmed by coronary angiography were used as the control group. Values of high sensitivity C reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein (apo)-A 1 , apo-B and fasting plasma glucose (FPG) were measured by fasting blood before radiography. Plasma PCSK9 and LPS levels were measured by enzyme-linked immunosorbent assay. Results The levels of PCSK9, LPS, hs-CRP, LDL-C, TC, apo-B and fasting blood glucose were significantly higher in ACS group than those in SAP group and control group (P<0.05), and HDL-C was lower than that of the control group (P < 0.05). PCSK9, LPS, LDL-C and apo-B levels were higher in SAP group than those of control group. The levels of plasma PCSK9 were positively correlated with LPS, hs-CRP,LDL-C, TC and apo-B in ACS patients (r = 0.509, 0.373, 0.516, 0.479, 0.470, all P < 0.05). Conclusion Plasma PCSK9 and LPS are involved in the development of coronary atherosclerosis. PCSK9 may play an important role in the pathogenesis of ACS by participating in the inflammatory reaction and lipid metabolism.