DOI: 10.11958/59086
The studying of fosinopril combined with fenofibrate on the preventing of diabetic retinopathy in diabetic mice
KUANG Jinsong
ZHAO Yurong
ZHAO Yuyan
Li Ruoxi
Xin Caihong
Abstract：Objective To study the effect and mechanism of the Fosinopril combined with Fenofibrate on the prevent?ing of diabetic retinopathy. Methods A total of 150 viripotent ICR mice(100 male mice, 50 female mice) were randomly di?vided into five groups(n=30), including A group (Sham group), B group (Model group), C group [Fosinopril prevented group, 20 mg/(kg·d)], D group [Fenofibrate prevented group, 400 mg/(kg·d)] and E group (Fosinopril combined with Fenofibrate pre?vented group). The expression levels of Bax and Bcl-2 gene mRNA were determined by RT-PCR method. TUNEL staining method was used to detect the apoptosisi of retinal cells. Results The Bcl-2 mRNA of A group, Bax mRNA of B group were higher than those of other four groups. Bcl-2 mRNA of E group was higher than that of C group and D group, while the Bax mRNA was lower than those of two groups(all P<0.05). The TUNEL index of B group was the highest than other groups, which of E group<D group<C group<B group(all P<0.05), and which of A and E groups were similar. The activi?ties of GSH-PX and SOD of B group were lower than those of other four groups, while the levels of ROS, MDA, VEGF were higher than those of them, the activity of GSH-PX and SOD of E group were higher than those of C and D groups, while the levels of ROS, MDA, VEGF were lower than them(all P<0.05). Conclusion Fosinopril and Fenofibrate can improve dia?betic retinopathy through inhibiting the apoptosis and antioxidation. The combination of them can get even better effect.
Keywords：diabetic retinopathydiabetes complicationsoxidative stressapoptosisdisease modelsanimalFosino-prilFenofibratevascular endothelial growth factor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 322-326 )