DOI: 10.11958/59129
Therapeutic effects of Bu-shen-he-mai-fang (HMF) on inflammation in atherosclerosis
Abstract：Objective To observe the therapeutic effect and mechanism of Bu-shen-he-mai-fang (HMF) on experi-mental atherosclerosis (AS) in apolipoprotein-E knockout(ApoE-/-)mice. Methods Twenty-four male ApoE-/-mice were randomly divided into three groups including high-fat group (0.25%cholesterol and 15%cocoa butter), HMF group [(high-fat diet+HMF decoction 1.37 g/(kg · d)] and atrovastatin group [(high-fat diet+atrovastatin 5 mg/(kg · d)], 8 mice for each group. The serum level of lipid was evaluated by a kit. The extent of AS was evaluated by HE staining. The macrophage infil-tration and expression of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) and interleukin-8 (IL-8) were evaluated by immunohistochemical staining. Results The serum level of lipid was lower in HMF group and atrovastatin group than that in high-fat group (P<0.05). The degree of AS was significantly lower in HMF group and atrovastatin group than that in high-fat group. The macrophage infiltration, TNF-α, IL-1βand IL-8 expressions were significantly lower in HMF group and atrovastatin group than those in high-fat group (P<0.05). Conclusion The results suggest that HMF significantly in-hibits early atherosclerotic lesions by lowering serum lipid level and inhibiting inflammatory response.
Keywords：atherosclerosisinflammationtumor necrosis factor-alphainterleukin-1betainterleukin-8Bu-shen-he-mai-fang
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 185-187,后插2 )