Correlation of left ventricular ejection fraction as well as serum levels of NT-proBNP, Hcy and D-D with different traditional Chinese medicine syndrome types of chronic heart failure
WEN Xuehong
YAN Weili
MA Mingkun
YANG Longyan
Abstract：Objective To investigate the correlation of left ventricular ejection fraction (LVEF) as well as serum levels of NT-proBNP, Hcy and D-Dimer (D-D) with different traditional Chinese medicine (TCM) syndrome types of chronic heart failure (CHF). Methods A total of 178 CHF patients were divided into heart function normal ejection fracture group (HF?NEF, n=86) and heart function reduction (HFREF, n=92) according to their LVEF performance. Another 35 cases with nor?mal cardiac function were included in control group. All CHF patients was also divided into 3 TCM syndrome types:"both de?ficiency of Qi and Yin syndrome group"(n=64),"Qi asthenia causing blood stasis syndrome group"(n=59) and"Yang defi?ciency water stop group" (n=55). All patients were examined with cardiac color doppler and LVEF values were recorded. And serum NT-proBNP、Hcyand D-D levels were all quantified. Results As to serum levels of NT-proBNP, Hcy and D-D, they were higher in HFREF group than those in HFNEF group than those in control group. On the other hand, LVEF was lowest in HFREF group but highest in control group. All differences were statistically significant (P<0.05). Among patient in HFNEF group, LVEF in the"Yang deficiency water stop group"was lower than that in"both deficiency of Qi and Yin syn?drome group"(P<0.05). Serum levels of NT-proBNP, Hcy, and D-D were not significantly different between different TCM syndrome groups. By contrast, among patients in HFREF group, LVEF values did not differ significantly between different TCM syndrome groups. Serum level of NT-proBNP was lower in"both deficiency of Qi and Yin syndrome group"than that in"Qi asthenia causing blood stasis syndrome group" than that in "Yang deficiency water stop group". As to serum levels of Hcy and D-D, they are higher in"Yang deficiency water stop group"that those in"both deficiency of Qi and Yin syndrome group" and "Qi asthenia causing blood stasis syndrome group"(P<0.05). Conclusion Patients with different TCM syn?drome types of CHF present different levels of serum NT-proBNP, Hcy, D-D level and LVEF. Changes of indicators in HFREF groups are more obvious than they did in HFNEF group.
Keywords：heart failurestroke volumenatriuretic peptidebraintraditional Chinese medicine syndrome typesLVEFNT-proBNPHcyD-dimer
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 624-627 )