Comparison Research on the Blood Loss after Total Knee Arthroplasty between Tranexamic Acid Single Dose Intra-articular Injection of Tranexamic Acid and Autologous Blood Transfusion Drainage Systems
WANG Lei
LIU Jun
SHI Bo
SUN Yunbo
ZHANG Yu
ZHAO Huiwen
SUN Zhenhui
Abstract： Objective To compare the efficiency of intra-articular injection of tranexamic acid (TXA) and autolo-gous transfusion drain on the blood loss after total knee arthroplasty (TKA). Methods A total of 124 patients (124 knees) with varus knee osteoarthritis, who were performed TKA,were retrospectively analyzed. Patients included 24 males and 100 females. The mean age was(65.03±6.84)years. Due to the blood loss control method, patients were divided into two groups including TXA application group (test group, n=49) and autologous transfusion drain group (control group, n=75). The data of blood routine examination, blood loss and blood transfusion after TKA were analyzed. Results The blood transfusion rates were 10.20%(5/49) in test group and 17.33%(13/75) in control group 7 days after TKA surgery. There was no signifi-cant difference between two groups (P>0.05). There were significant differences in red blood cell (RBC), hemoglobin (Hb) and haematocrit (HCT) between groups and effects of interaction in the two groups (P<0.01). There were significantly higher values of RBC, Hb and HCT at 1, 3 and 7 days after surgery in test group than those of control group (P<0.05).The total blood loss 1 and 3 days after TKA was significantly lower in test group than that of control group (P<0.05). There was no sig-nificant difference in the blood loss 7 days after surgery between two groups (P>0.05). Conclusion The single dose intra-articular injection of tranexamic acid is a safe and effective procedure for hemostasis after TKA.
Keywords：knee prosthesisarthroplastyreplacementkneetranexamic acidblood transfusionautologousblood losssurgical
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 779-781 )