Pathogenic Factors and Mechanism of Hypertension in Obese Children

doi:10.3969/j.issn.0253-9896.2001.05.001

Abstract：To explore the mechanism of obesity-induced hypertension in children. Method: The levels of serum lipid, serum insulin (Ins) and cell membrane ATPase activities were measured in 104 middle school children aged 12～16 years. Results:The level of serum Ins was significantly higher,and the activities of Na + -K+ -ATPase and Ca2+ -ATPase were sig- nificantly lower in obese normotensive (ONT) and obese hypertensive (OHT) children than those in normal children. There were also significant differences in them between ONT and OHT children, the level of serum Ins was increased and the ac- tivities of the two ATPases were lowered in OHT children. Pearson correlation and multiple regression analysis shown that the level of Ins and the activity of Ca2+ -ATPase were correlated with systolic pressure and the activity of Na+ -K+ -ATPase was corrlated with diastolic pressure in OHT children. Conclusion: Hyperinsulinemia and decreased activities of Na+ -K+ - ATPse and Ca2+ -ATPase may play important roles in pathogenesis of hypertension in obese children.