Kinetic Alterations of Blood Myocardial Troponin I and Multiple Enzymatic Markers in Early Myocardial Damnification

doi:10.3969/j.issn.0253-9896.2001.04.012

Abstract：Objective:To explore kinetic alterations and disciplinarian of blood myocardial troponin I and enzymatic markers in early of myocardial injury. Methods:The cardiac injury models of adult New Zealand rabbits were made by ear vein instillation with isopropyl epinephrine(10mg/kg b. w. ). The levels of myocardial troponin I (cTn I), creatin kinase (CK), aspartate transamnase(AST)and lactatede hydrogenase(LDH)were detected before and per 30 mins during the experiment, and the changes of rabbit myocardial pathology were analyzed. Results:The myocardial pathology of early rabbit models demonstrated that cardiac muscle space became wider, inflammatory cell infiltrated with mostly neutophil granulocytes, part caidiac muscle fibres became thinner and the space became significant wider,loosen,and edema accompanied with the infiltration of plasma cells,lymphocytes and little neutrophil granulocytes at 4 h. The activity of AST was 20% during the cardiac muscle injury and no significant difference was found between groups (P＞0.05). The LDH activity wasn't obvious 2 h before and doubly increased at 4 h. CK activity was significant abnormity (P＜0.05) and increased five times at the end of experiment. The change of cTnI wasn't obvious at the first 90 mins, and was significant abnormity (P＜0.05) at 2 h and increased four times at 4 h. Positive correlation was found between CK, LDH and cTnI except AST( r＞0.96). Conclusion:Abnormal concentrations of CK and cTnI in peripheral blood are the most sensitive markers for early cardiac muscle injury.