Dynamic Observation on Intracellular Adhesion Molecular of Small Bowel ransplantation Graft of Rat
Abstract：Objective: To study the ralationship between the rejection and intracellular adhesion molecular (ICMI-1) of small boweltransplantation graft of rat and the action of rapamycin (RAPA) on it. Methods: Pseudooperated SD rats acted as control(group 1) and hetero-intestinal allotransplanted rats acted as model. Based on different treatment, these tested rats were di-vided into 3 groups:rejection (group 2),PARA 2 mg/kg(group 3) and PARA 4 mg/kg groups (group 4). All rats werekilled and their small bowel transplantation graft were harvested for pathologic and ICMI-1 immunohistochemical tests onPOD 1,3,5 and 7, respectively. Results:The pathological evidences of rejection were not detected in all groups on POD 1,3.There were episodes of I0 and II0 rejections in Group 2 on POD 5,7 respectively. On POD 7, the mild rejection happened ingroup 3,and no rejected trail existed in group 4. Only a little ICMI-1 expression in endothelium and lamina propria in controlgroup,but the quantity of ICMI-1 expression in the same place reached a peak in rejection group on POD 5. There were sig-nificant differences in expression of lymphocyte and interstitial cell between the test and control groups. Conclusion: ICMI-1takes part in the rejected process of small bowel transplantation. RAPA not only inhibits rejection,but also inhibits expres-sion of ICMI-1 in small bowel transplantation.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 168-170 )