Changes of PLA2,GR and Water-content after Cerebral Contusion in Rats
Abstract：Objective:To investigate the relative changes of PLA2 activity, GR,and water-content in local cerebrum after injury.Methods:PLA2 activity,GR and water-content in cerebrum on the injured side were detected using a model of fluid perfus
sion injured rat brain. Results:PLA2 increased 1 hour after injury,then get the peak at 12～24 hours,and gradually de
creased 72 hours after injury. GR significantly decreased at 6～12 hours,and came back to 70% of the control group level 72
hours after injury. Water-content gradually increased at 6 hours after injury. Conclusion:The pathological rising of PLA2 ac
tivity is relative to cerebral ischemia and cerebral edema on the injured side of the brain. The change of GR plays an impor
trant role in low suppressive effect of PLA2.There was a negative correlation between PLA2 and GR from early stage to 72
hours after injury. The suppressive effect of glucocorticoid (GC) to PLA2 is relative to GR. The treatment of high close of
DEX at early stage of injury can effectively decrease cerebral edema.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 94-96 )