Role of Nilestriol in Inhibiting Expression of Interleukin-6 Messenger Ribonucleic Acid (RNA) in Ovariectomized Rat Bone
Abstract：Objective: To investigate the effect of nilestriol on the expression of interleukin-6 mRNA in ovariectomized (OVX) rat
bone. Methods:Thirty female Wistar rats with the age of 3 months were randomized into 3 groups with 10 rats each which
included OVX, sham,and nilestriol groups. One week after ovariectomy, the nilestriol group was given nilestriol once a week
for 13 weeks. All rats were killed 3 months postoperatively. Total RNA was isolated directly from bone,and the expression
of IL-6 mRNA was detected using reverse transcription-polymerase chain reaction technique. Results: The level of IL-6 mR
NA was lower in nilestriol group than that in OVX group (P < 0.01 ),and there was no significant difference between
nilestriol and sham groups. Conclusion: IL-6 plays a role in the pathogenesis of posunenopsusal osteoporosis. Nilestriol can in
hibit the expression of IL-6, reduce bone resorption, and maintain bone volume.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 91-93 )