Influence of General Anesthesia Combined with Epidrual Blockade on Stress and Immune Function in Upper Abdominal Surgery
XU Chen
JIANG Jianyu
Abstract：Objective: To study the effects of general anesthesia combined with epidural blockade on stress response and immune
function by measuring of IL-2,sIL-2R,CA,and eortisol in upper abdominal surgery. Methods: Thirty patients who under
went upper abdominal operation were randomized into two groups which included general anesthesia group (group G,n=
15) and general anesthesia combined with epidural blockade group (group G+ E,n = 15). Peripheral venous blood samples
were obtained in all patients before and after induction of anesthesia,at the end of operation,and 1 ,and 3 days postopera
tively. Results:Epinephrine (E) increased at the end of operation and 1 day postoperatively in group G (P＜0.01),and
there was no significant change in group G + E (P ＞ 0.05). Norepinephrine (NE) decreased after anesthesia induction in
group G + E (P＜0.05) ,and there was no significant change at the end of operation, 1 ,and 3 days postoperatively (P＞
0.05). In group G,NE significantly increaed at the end of operation, 1, and 3 days postoperatively (P＜0.01 and P＜
0.05, respectively). Cortisol decreased after anesthesia in two groups (P＜0.05). IL-2 decreased at the end of operation in
group G (P＜0.05 ), and there was no change in group G + E. There was no significant change of sIL-2R in two groups af
ter anesthesia and operation (P＞0.05). Conclusion:Combined anesthesia in a more effective method in suppressing stress
and protecting immune function in upper abdominal surgery than simple general anesthesia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 78-81 )