Changes of Endothelium Function,Fibrolysis Activity and Platelet Activation in Diabetic Angiopathies
Abstract：Objective:To investigate the changes of endothelium function (vWF, TM), fibrolysis activity (t-PA, PAI-1), and
platelet activity in patients with (group A) and without (group B) diabetic angiopathies. Method:vWF was detected by im
munoeletrophoresis. TM and GMP-140 were examined by ELISA. t-PA and PAI-1 were determined by ehromogenic assay.
PAgT was certained by turbidimetry. Results:The concentration of vWF,TM,PAI-1 ,and GMP-140 in blood were higher in
both group A and group B than those in control group,and were higher in group B than those in group A. The concentration
of t-PA was higher in group B than that in group A and control group. PAgT was higher in group B than that in control
group ( P＜0.05). Conclusion: The vessel endothelia are damaged in the early phase of DM, and this damage is more serious
in patients with angiopathies. The dangerous factor of thrombosis are high level of coagulation and fibrolysis, and increased
PAI-1. GMP-140 is a sensitive indicator for platelet activation.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 71-73 )