Relationship between Monophasic Action Potentials and Ischemic Arrhythmias in Acute Myocardial Infarction Canine
Abstract：To investigate the relationship between parameter changes of monophasic action potentials (MAP) and ischemic myocardium triggered activity and ischenic arrhythmias. Methods:The records of Ⅲ° AVB and 30 minute ischemia under the stimulation of PES were performed with Frarz electric pole in 12 anesthetized dogs. Results:MAP amplitude decreased from (19.04±8.66) mV to (10.34 ± 8.29) mV at 30 minutes of myocardial ischemia in control group (P＜0.01), and MAP-D50 changed from (205.71 ± 30.17) ms to ( 172.14 ± 34.05) ms ( P ＜ 0.01 ). The afterdepolarizations were recorded in 6 of 12 dogs. EAD-induced triggered activity was observed in 2 dogs (33.3%) ,and DAD-induced in 1 dog ( 16.7 % ). There was a positive correlation between EAD amplitude and cycle length ( r = 0.87, P ＜0.05), RCL and PCL ( r = 0.84, P ＜0.05), and 36.4 % VTs showed acceleration to overdrive. Conclusion: MAP recording can be used as a reliable electrophysilogic index for evaluation ischemia. This finding, supports the role of triggered activity resulted from EAD as well as in the genesis of ischemic arrhythmias in vivo.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 38-40 )