Role of Experimental L-Arginine Supplement in Improving Gentamycin Nephrotoxicity
Abstract：To work over the role and mechanism of L-arginine (L-Arg) supplement in improving gentamycin (GM) nephrotoxicity. Methods:By means of Wistar rats, the items of investigation were comprised of morphologic changes of kidney, concentrations of creatinine (Cr), bicarbonate ( HCO3- ) and metabolic products of nitric oxide ( NOx- ) in blood and urine, urine glucose, protein and dynamic changes of N-acetyl-β-D-aminoglucosidase (NAG),et al. Results :After L-Axg supplement,most of morphologic changes caused by GM nephrotoxicity were ameliorated;urine NOx- level was increased, whileserum NOx- level was less influenced;the delayed increase of urine NAG was noticed;but a metabolic acidosis was induced accompanied with increased serum Cr and aggravated glucosuria and proteinuria. Conclusion:Although the L-Arg has a protective role in kidney damage caused by GM nephrotoxicity, it may also produce some disadvantageous effects on the body.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 34-37 )