Effect of Astragali on Tumor Necrosis Factor and Lipoprotein (a) in Hemodialyzed Patients
Abstract：To explore the effect of astragali on tumor necrosis factor- (alpha) (TNF-α) and lipoprotein (a) 〔 Lp(a) 〕 in hemodialyzed (HD) patients. Methods:Double antibody sandwich ELISA and RIA were used to determine serum Lp(a) and TNF-α levels from 21 HD patients (pre-and post-hemodialysis, after astragali treatment). Results: Serum TNF-α, Lp(a),apolipoprotein B (apo B), total cholesterol ( TC ), triglyceride ( TG ), low density lipoprotein-cholesterol (LDL-c) and very low density lipoprotein-cholesterol (VLDL-c)concentrations in H-D patients were significantly higher than those in control (P ＜0.01). Serum apo A1, apo A1/apo B and high density lipoprotein-cholesterol (HDL-c) levels were significantly lower than those of normal control (P ＜0.01). There were no changes of TNF-α and lipid levels in 21 HD patients between preand post-hemodialysis (P＞ 0.05 ). After astragali treatment, the levels of TNF-α, Lp (a), TC, TG, LDL-c and VLDL-C were decreased (P＜0.05 or P＜0.01) ,and the levels of apo Al,apo Al/apo B,HDL-c were increased (P＜0.05 or P＜0.01 ). Conclusion: (1)The continuous HD patients were characterized by the increased TNF-α and hyperlipoproteinemia.(2)The disorder of TNF-α and lipid metabolism could not be corrected with HD. (3)The astragali treatment could improve the disorder of TNF-α and lipid metabolism in HD patients.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 9-11 )