Study of Mechanism of Adenosine Antagonized Isoproterenol on Action Potentials andlnward Rectifier Potassium Channels in Guinea Pig Papillary Muscles and Ventricular Myocytes
Abstract：Objective: To investigate the mechanism of adenosine antagonized isoproterenol on action potentials and inward rectifierpotassium channels in guinea pig papillary muscles and ventricular myocytes, and to demonstrate the ionic current basic inthe treatment with adenosine. Methods:Standard glass microelectrode method and whole cell patch clamp techniques wereused to study the effect of adenosine on action potential and Ica-L, IKl. Results: ISO prolonged APD, urged EAD, delayed DADand triggered activity, and increased ICa-L and IKi. APD prolongation caused by ISO, and Iki, and Ica-L were inhibited byADO. The effect of ADO was antagonized by DPCPX. Conclusion: Openings of IKl may shorten APD with the protection formyocytes. There is a correlation between the effect of ADO to APE caused by the antagonized effect to ISO and Ica-L and Iklinhibition.
Keywords：adenosine potassium channels action potentials myocardium
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 671-674 )