The Experimental Study of the Protective Effect of 1,6-Fructose Diphosphate on the Secondary Damage in Brain lnjury
Abstract：Objective:To discuss the protective effect of 1,6-fructose diphosphate(FDP)on secondary damage in brain injury andits mechanism. Methods: Six hours after brain injury, the contents of lipoperoxide( MDA)and superoxide dismutase( SOD)inblood and brain tissue as well as glucose and C-peptide in blood of Wistar species rates were examined. The brain tissue sam-p les were checked under hght and electric microscope. Results: FDP made the MDA contents of brain tissues and plasma andthe c-peptide level in serum dropped, inhibited blood glucose elevation, kept the SOD activity of brain in a high level and increased the SOD activity of erythrocyte so as to lighten the edema of neuron and gliocyte and the damage of mitochondrion.Conclusion: FDP is of a certain protective effect on secondary damage in brain injury. This effect is related to reducing the lipoperoxidized reaction,inhibiting blood glucose elevation, improving oxygen utilization of mitochondrion and stabilizing bi-omembrane.
Keywords：fructosediphates brain injuries
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 668-670 )