The Significance of Neutrophil Alkaline Phosphatase Activity in Differential Diagnosis for the Fever of Unknown Origin of Children
Abstract：Objective:To explore the significance of the neutrophil alkaline phosphatase (NAP) in differential diagnosis for the fever of unknown origin(FUO) of children. Methods: The NAP activities determined by Naphthol AS-BI phosphate of 63 FUO children (FUO group) and 50 healthy children ( control group) were expressed by the positive rate and the positivescore. Results:There was no significant difference in the positive rates between the FUO group(71.3% ±24.1% )and thecontrol group(74.6% ± 11.7% ). There was a very significant difference in the positive scores between the FUO group(138.7 ± 78.6) and the control group(95.3± 26.5)( P ＜ 0.01 ). In the FUO group, the NAP positive rate and score inbacterial infection group(87.6 % ± 12.9 % and 196.0 ± 76.3)were much higher than those in viral infection group(48.7 %± 21.8 % and 69.9 ±39.3)( P ＜ 0.01 ). Conclusion: The NAP activity is of important significance in differential diagnosisfor FUO children , especially in identifying bacterial infection or viral infection. Compared with the positive rate, the positivescore is more important.
Keywords：alkaline phospbatase neutrophil fever children
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 654-656 )