The Mechanism of Hypertensive Factor in Patients with Non-lnsulin-Dependent Diabetes Mellitus
Abstract：Objective:To find out the level of hypertensive factor (HF) and changes of its correlative ion transport enzymes in patients with non-insulin-dependent diabetes mellitus (NIDDM) and to probe into the mechanism of their effects on blood pressure (BP). Methods:The HF activities of 32 patients with NIDDM and 33 healthy controls were measured with a biologically active method, and the activities of Na2+ -K2 + -ATPase and Ca2 + -Mg2 + -ATPase were measured with a chemical method. Results:There was a significant difference in HF positive rate between NIDDM group (56%) and control group (30%)(P<0.05). The activity of Na2+ -K2+ -ATPase in patients with positive HF (1.24 ± 0.40) were higher than that in patients with negative HF (0.85 ± 0.32)(P < 0.05). Conclusion: It may be ralated to the increased Na2+ -K2 + -ATPase activity that HF could not induce the rise of BP in diabetic patients.
Keywords：diabetes mellitusnon-insulin-dependent Na( + ) -K( + ) -Exchanging ATPase Ca2 + Mg2 + -ATPese
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 643-646 )