Study on the Correlation between Cardiac Function Prognosis and Serum Uric Acid and High-sensitivity Cardiac Troponin Ⅰ Levels in Patients with Acute Myocardial Infarction

JIN Rong; ZHAN Hongju; MEI Xiao; LI Zhaoyang

doi:10.16458/j.cnki.1007-0893.2026.01.002

Abstract：Objective To explore the relationship between serum uric acid(SUA)and high-sensitivity cardiac troponin Ⅰ(hs-cTnI)levels and cardiac function prognosis in patients with acute myocardial infarction(AMI).Methods A total of 141 AMI patients admitted to the Panyu Branch of the Second Affiliated Hospital of Guangzhou Medical University from January 2023 to December 2024 were selected as the research subjects.Their SUA and hs-cTnI levels were detected,and echocardiography was performed to record left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and the degree of coronary artery disease(Gensini score).The severity of patients'heart failure was evaluated according to the Killip classification,and the patients were divided into the Killip grade≥Ⅱ group and the Killip grade<Ⅱ group.The differences in SUA and hs-cTnI levels between patients of different Killip grades and patients with different types of myocardial infarction were compared,and correlation and multivariate regression analyses were conducted.Results:There was no statistically significant difference in general data between the Killip grade≥Ⅱ group and the Killip grade<Ⅱ group(P>0.05);there were statistically significant differences in SUA levels and peak serum hs-cTnI levels among patients with Killip grades I to IV(P<0.05);the SUA levels and peak serum hs-cTnI levels of patients with ST-segment elevation myocardial infarction(STEMI)were higher than those of patients with non-ST-segment elevation myocardial infarction(NSTEMI),and the differences were statistically significant(P<0.05).The correlation analysis showed that the SUA levels and peak serum hs-cTnI in AMI patients were negatively correlated with LVEF and positively correlated with LVESD,LVEDD,and Gensini score(P<0.05).Multivariate regression analysis showed that after adjusting for confounding factors,SUA and peak hs-cTnI remained independent risk factors for Killip classification≥II heart failure in patients(P<0.05).Conclusion The SUA and peak hs-cTnI levels in AMI patients are significantly correlated with the severity of Killip classification,and their elevation is an important risk factor for cardiac function deterioration.